10:00 Relative potencies of selected opiate and opioid analgesics in disruption of food reinforced operant behavior and self-administration. Robert L. Balster and Louis S. Harris, Virginia Commonwealth University, USA.
10:30 Ethanol as an oral reinforcer for rhesus monkeys: maintenance of fixed-ratio responding. Jack E. Henningfield and Richard A. Meisch, University of Minnesota, USA.
11:00 Self-administration of morphine in the cat. M. Marlyne Kilbey and Everett H. Ellinwood, Duke University Medical Center, USA.
11:30 The effects of changes in reinforcement magnitude on responding maintained by injections of cocaine or pentobarbital. Chris E. Johanson, The University of Chicago, USA.
12:00 Drinking and lever-press behavior: oral self-administration of morphine in non fluid-deprived rats. Robert J. Filewich, The University of Mississippi, USA.
12:30-2 Lunch — "Refectory of the Academy"
2:00 Intravenous heroin and morphine reinforcement for T-maze learning. P.D. Tomporowski and W.F. Crowder, The University of Mississippi, USA.
2:30 Naloxone-precipitated abstinence in the rhesus monkey: comparison of the intracerebral and intravenous routes of morphine-antagonist administration. Juan Sanchez-Ramos, The University of Chicago, USA.
3:00 Comparison of behaviors maintained by infusions of several substituted phenylethylamines in baboons. Roland Griffiths, Johns Hopkins Medical School, USA.
3:30 Cocaine self-administration under schedules of delayed reinforcement in squirrel monkeys. Roger Stretch and Gary Gerber, University of Ottowa, Canada.
4:00-5:00 Business meeting
MORNING SESSION CHAIRPERSON: ROLAND GRIFFITHS
9:00 Registration
9:20 Opening remarks, Charles R. Schuster, The University of Chicago, USA.
9:30 Cocaine-reinforced progressive ratio performance in the rhesus monkey. John A. Bedford and Marvin C. Wilson, The University of Mississippi, USA.
10:00 Procaine self-administration in rhesus monkeys. Robert D. Ford, Robert L. Balster, George W. King, Thomas G. Aigner and Louis S. Harris, Virginia Commonwealth University, USA.
10:30 The reinforcing properties of procaine in macaca mulatta. D.M. Hammerbeck and C.L. Mitchell, Riker Labs.
11:00 Modification of food and codeine reinforced responding by narcotic antagonists. John M. Carney, Virginia Commonwealth University, USA.
11:30 Testing for reinforcing properties of psychotropic drugs in rats. James R. Weeks, R. James Collins and Phillip I. Good, The Upjohn Company, USA.
12:00: LUNCH
AFTERNOON SESSION CHAIRPERSON: ROBERT L. BALSTER
1:30 Resistance to punishment as a potential measure of drug-reinforcer efficacy. Robert N. Grove, Laval University, Canada.
2:00 Fixed-interval and fixed-ratio responding maintained under second-order schedules of cocaine injection in squirrel monkeys. Steven R. Goldberg and R.T. Kelleher, Harvard Medical School, USA.
2:30 Response durations in intravenous cocaine self-injection. J. Dougherty, D. Miller and A. Wikler, Lexington Veterans Administration Hospital, USA.
3:00 ISGIDAR business meeting
9:00 Registration
9:30 Intravenous nicotine self-injection in rats. John Dougherty, D. Miller and S. Adams, Lexington Veterans Administration Hospital, USA.
10:00 Discriminative stimulus properties of narcotics and prediction of drug abuse. F.C. Colpaert, Janssen Pharmaceutical Research Laboratories, Belgium.
10:30 Establishing ethanol as a reinforcer in food and water satiated animals. Henry Marcucella (Boston University) and James S. Macdonall (Washington Center for Addictions), USA.
11:00 Overcrowding of mice increases naloxone-induced jumping with or without chronic morphine exposure. G. Etra and Kenneth A. Bonnet, New York University Medical Center, USA.
11:30 Pentazocine-reinforced responding in the squirrel monkey: Effects of dose and fixed-ratio size. Carol Iglauer, Lexington Veterans Administration Hospital, USA.
12:00 Lunch
1:30 A food-drug choice procedure for evaluating drug reinforcement efficacy in rhesus monkeys. Thomas G. Aigner and Robert L. Balster, Virginia Commonwealth University, USA.
2:00 Animal model of chronic oral drug self-administration. Paul K. Brandon, Mankato State College, USA.
2:30 Etonitazene as a reinforcer for rats: Effects of concurrent access to water and determinants of etonitazene intake. Marilyn E. Carroll and Richard A. Meisch, University of Minnesota, USA.
3:00 Concurrent intracranial self-stimulation and amphetamine self-administration in rats. Gary Gerber, Roy A. Wise and Robert A. Yokel, Concordia University, Canada.
3:30 The effects of chronic naltrexone on morphine self-administration. Steve Harrigan and David Downs, Parke David & Company, USA.
Self-administration of l-alpha-acetylmethadol (LAAM) and its N-demethylated metabolites, Nor-LAAM and Di Nor-LAAM, in the dependent rat. Gerald A. Young, J. Edward Moreton, George F. Steinfels and Naim Khazan, University of Maryland School of Pharmacy, USA.
Effects of lithium on choice behavior between food versus cocaine in rhesus monkeys. William Woolverton, J. Marshall Newbern and Robert L. Balster, Medical College of Virginia, USA.
Self-administration of drugs in the dog. Marc Risner, Addiction Research Center at Lexington, USA.
Effects of brief stimuli correlated with the availability of food on responding maintained by intravenous codeine. Alice M. Young, Marilyn Jensen, Laurie Rice and Travis Thompson, University of Minnesota, USA.
Control of extended sequences of drug-seeking behavior by environmental stimuli. Steven R. Goldberg and Roger D. Spealman, New England Regional Primate Research Center, USA.
Medial forebrain bundle lesions selectively attenuate self-administration of amphetamine, cocaine and apomorphine in rats. Gary J. Gerber and Roy A. Wise, Concordia University, Canada.
Are there positively reinforcing effects of drugs with abuse potential mediated by the opiate receptor? Stanley R. Lorens, Loyola University Medical Center, USA.
Metabolic factors in human drug self-administration. Roy C. Pickens and Phillip M. Catchings, University of Minnesota Medical School, USA.
Effects of food deprivation on etonitazine consumption in rats. Marilyn E. Carroll, Richard A. Meisch and Charles France, University of Minnesota Medical School, USA.
Business meeting
8:45 Registration
9:00 Effects of feeding conditions on drug-reinforced behavior. Marilyn E. Carroll, Charles P. France and Richard A. Meisch, University of Minnesota, USA.
9:30 Comparison of macaca nemestrina and macaca mulatta in narcotic self-administration procedures. Alice M. Young and James H. Woods, University of Michigan, USA.
10:00 Intravenous self-administration of cyclazocine in rhesus monkeys. Tomoji Yanagita, Central Institute for Experimental Animals, Japan.
10:30 Coffee
11:00 Antagonist effects on morphine and heroin self-administration in rhesus monkeys. David A. Downs and Stephen E. Harrigan, Warner-Lambert/Parke Davis, USA.
11:30 Buprenorphine: effect on heroin self-administration in addicts. Nancy K. Mello, Jack H. Mendelson, John C. Kuehnle and Margaret L. Sellers, Harvard Medical School, USA.
12:00 Lunch
1:30 Intravenous nicotine self-administration in rhesus monkeys. John Dougherty and Dianne B. Miller, Veterans Administration Hospital at Lexington, USA.
2:00 Human cigarette smoking: effect of dose manipulations on pattern of self-administration. Jack E. Henningfield and Roland R. Griffiths, The Johns Hopkins University School of Medicine, USA.
2:30 Coffee
3:00 Relative reinforcing effects of cocaine and procaine in rhesus monkeys: substitution vs. choice procedures. Chris E. Johanson and Tom G. Aigner, University of Chicago School of Medicine, USA.
3:30 Comparison of second-order schedules of cocaine injection and food presentation in squirrel monkeys: effects of d-amphetamine and promazine pretreatment. Jonathan Katz, Harvard Medical School, USA.
4:00 Business meeting
8:30 Registration
9:00 Effects of durations between ethanol deliveries and concentration on ethanol-reinforced behavior in rats. Patrick M. Beardsley, Gregory A. Lemaire and Richard A. Meisch, University of Minnesota Medical School, USA.
9:30 Orally delivered pentobarbital as a reinforcer for rhesus monkeys with concurrent access to water: effects of concentration, fixed-ratio size and liquid position. Victor J. DeNoble and Richard A. Meisch, University of Minnesota Medical School, USA.
10:00 Methohexital-reinforced responding in rats: effects of fixed-ratio size and injecton dose. Roy Pickens, David Muchow and Victor J. DeNoble, University of Minnesota Medical School, USA.
10:30 Coffee and tea
11:00 Amphetamine-like effects of some monoamine oxidase inhibitors (MAOI) and other antidepressants in a drug discrimination procedure. Roger D. Porsolt, Centre de Recherche Delalande, France.
11:30 Reinstatement of extinguished responding for cocaine responding for cocaine reinforcement by non-contingent drug infusions, and by conditioned stimuli associated with drug infusions. Harriet de Wit, The University of Chicago, USA.
12:00 Lunch
2:00 Discrimination of tetrabenazine by rats: a possible model to evaluate the antidepressant action of drugs which act as reinforcers. R. Sue Sutherland (Chatham College) and Stephen Miksic (Western Psychiatric Institute and Clinic), USA.
2:30 The behavioral pharmacology of local anesthetics. William L. Woolverton, Earl E. Dowdy, Jr. And Robert L. Balster, Medical College of Virginia, USA.
3:00 Discriminative stimuli produced by the vasodilator, hydralazine. Debra A. Bennett and Harbans Lal, University of Rhode Island, USA.
3:30 Generalization of LSD and apomorphine cues to ergot alkaloids: serotonin and dopamine mechanisms. James B. Appel, A.M. Holohean and F.J. White, University of South Carolina, USA.
4:00 ISGIDAR Business Meeting
7:45 Behavioral studies on (+)-isomers of opioids. John M. Carney, University of Oklahoma Medical School, USA.
8:15 A pharmacological analysis of the discriminative stimulus "effects" produced by cyclorphan (3-OH-N-cyclopropylmethyl-morphinan). Seymore Herling, Rita J. Valentino, David W. Hein, Edward H. Coale, Jr., Gail Winger and James H. Woods, University of Michigan, USA.
8:45 Self-administration of sufentanil in the rhesus monkey. Alice M. Young and James H. Woods, University of Michigan, USA.
9:15 Nicotine and arecoline as discriminative stimuli: a comparison of central sites of action. Leonard T. Meltzer and John A. Rosecrans, Medical College of Virginia, USA.
9:45 Nicotine as a discriminative stimulus in humans: a preliminary investigation. John A. Rosecrans, Jean Harry, William Kallman and Mary Jeanne Kallman, Virginia Commonwealth University, USA.
10:15 Discrimination of altered methadone dosage by maintenance patients. Maxine Stitzer, George Bigelow and Ira Liebson, Baltimore City Hospital, USA.
8:30 Registration
9:00 Ethanol consumption as a function of ethanol availability periods. Henry Marcucella and Ilse Munro (Boston University) and James S. MacDonall (Fordham University), USA.
9:30 Oral self-administration of methohexital in the baboon. Nancy A. Ator and Roland R. Griffiths, The Johns Hopkins University School of Medicine, USA.
10:00 Diazepam self-administration in the rhesus monkey. Jack Bergman, Chris E. Johanson and Charles R. Schuster, The University of Chicago, USA.
10:30 Coffee Break
10:45 Pentobarbital-maintained progessive-ratio performance by humans. Daniel R. McLeod and Roland R. Griffiths, Baltimore City Hospitals and The Johns Hopkins University School of Medicine, USA.
11:15 A screening test for drug reinforcers using rats. R. Collins, J.R. Weeks and R.R. Russell, The Upjohn Company, USA.
11:45 A method for assessing the dependence potential of drugs in humans. Chris E. Johanson, E.H. Uhlenhuth and Charles R. Schuster, The University of Chicago, USA.
12:15 Lunch
2:00 Nicotine self-administration in rats. William T. Nelson, Jr. and Brian Cox, Addiction Research Foundation, Canada.
2:30 Schedule-induced nicotine self-administration in rhesus monkeys. Barbara E. Slifer and Robert L. Balster, Medical College of Virginia, USA.
3:00 Subjective and physiological effects of nicotine and nicotine self-administration in humans. Jack E. Henningfield, Katsumasa Miyasato, Rolley E. Johnson and Donald R. Jasinski, NIDA Addiction Research Center, USA.
3:30 An improved pneumatic syringe for self-administration of drugs. James R. Weeks, The Upjohn Company, USA.
4:00 Business meeting
8:30 Registration
9:00 Opening remarks: C.E. Johanson
9:15 Influence of physical dependence on reinforcing intensity of diazepam tested by the progressive ratio method in rhesus monkeys. T. Yanagita and N. Oinuma, Central Institute for Experimental Animals, Japan.
9:45 Oral self-administration of triazolam and diazepam in the baboon: effects of a benzodiazepine antagonist. N. Ator and R. Griffiths, The Johns Hopkins University School of Medicine, USA.
10:15 Coffee break
10:45 Antagonism of the discriminative stimulus effects of diazepam. S. Herling and H. Shannon, NIDA-ARC (Lexington), USA.
11:15 Comparison of threshold doses of discriminative stimulus and reinforcing effects tested with cocaine and barbital in crab-eating and rhesus monkeys. T. Yanagita, S. Kato and K. Takeda, Central Institute for Experimental Animals, Japan.
11:45 Mu vs kappa opioid agonists: self-administration and abstinence in the rat. G. Young and H. Khazan, University of Maryland School of Pharmacy, USA.
12:15 Lunch
1:45 Apomorphine self-administration in the rat. R. Wise, Concordia University, Canada.
2:15 A two-drug choice paradigm using self-administration by rats. J. Weeks and R. Collins, The Upjohn Company, USA.
2:45 Intragastric self-administration in rhesus monkeys. W. Woolverton and C. Schuster, The University of Chicago, USA.
3:15 Nicotine self-administration by squirrel monkeys and beagle dogs. S. Goldberg, M. Risner, NIDA-ARC (Baltimore and Lexington) and R. Spealman (New England Regional Primate Center), USA.
3:45 Business meeting
4:15 "Cocktail" Hour
9:00 Registration
9:30 The reinforcing properties of metazocine and its stereoisomers in rhesus monkeys. B.L. Slifer, R.L. Slifer and E.L. May, Medical College of Virginia, USA.
10:00 Oral self-administration of d-amphetamine, ketamine, methohexital and SKF 10,047 in rhesus monkeys using substitution procedures. M.E. Carroll, D.C. Stotz, D.J. Klimer aqnd R.A. Meisch, University of Minnesota, USA.
10:30 Self-administration of phenethylamines under different schedules of delivery. H. Shannon, Addiction Research Center (Lexington), USA.
11:00 Relationship between reinforcing and discriminative preference in humans. H. de Wit and C.E. Johanson, The University of Chicago, USA.
11:30 Relationship between reinforcing and discriminative effects of intravenous cocaine, pentobarbital and nicotine in rhesus monkeys. S. Kata, Y. Wakasa, K. Ando and T. Yanagita, Central Institute for Experimental Animals, Japan.
12:00 Lunch
1:30 Discriminative properties of dopamine agonists in rhesus monkeys. W.L. Woolverton, The University of Chicago, USA.
2:00 Drug discrimination in humans: methodological considerations. L.D. Chait and C.E. Johanson, The University of Chicago, USA.
2:30 Place preference conditioning in rats using ethanol as the US: modification by concurrent administration of food and social reinforcement. R.B. Stewart and L.A. Grupp, University of Toronto and Addiction Research Foundation, Canada.
3:00 Schedule-induced intake of midazolam in rats. J. Falk and M. Tang, Rutgers University, USA.
3:30 Behavioral differentiation of anxiolytic medication. F.R. Funderburk, R.R. Griffiths, G. Bigelow, I. Liebson and D. McLeod, Baltimore City Hospitals, USA.
4:00 Business meeting
9:00 Registration, coffee and doughnuts
9:30 The Effects of Haloperidol and Sodium Pentobarbital on Intravenous Self-Administration of Cocaine in Rats.
Yoshio Wakasa, Zhi-Ji Cai and Tomoji Yanagita, Central Institute for Experimental Animals, Japan.
10:00 Drugs as Reinforcers: Neurobiological Approaches. Nicholas E. Goeders and Steven I. Dworkin, Louisiana State University, USA.
10:30 Investigations of Specific Brain Regions and Neurotransmitter Systems Involved in Behavioral Drug Effects.
Steven I. Dworkin and Nicholas E. Goeders, Louisiana State University, USA.
11:00 Behavioral Studies with Direct Dopamine Receptor Agonists and Antagonists.
William L. Woolverton, The University of Chicago, USA.
11:30 Aversive Effects of Intravenous Drugs in Rhesus Monkeys: Escape Responding from Histamine.
Kohji Takada, University of Michigan, USA.
12:00 Lunch
1:30 Reinforcing Properties of Benzodiazepines in Rhesus Monkeys. Chris-Ellyn Johanson The University of Chicago, USA.
2:00 Self-Administration of Nicotine Gum.
John R. Hughes, Roy W. Pickens and William Spring, The University of Minnesota, USA.
2:30 Preference for Alcohol in Normal Volunteers.
Harriet deWit, E.L. Ulenhuth and Chris-Ellyn Johanson, The University of Chicago, USA.
3:00 Behavioral Pharmacogenetics: The Mouse as a Tool in Studies of Drug Self Administration.
Frank R. George and Richard A. Meisch, University of Minnesota, USA.
3:30 Reduction in Phencyclidine Self-Administration by Concurrent Availability of an Alternative Reinforcer.
Marilyn E. Carroll, University of Minnesota, USA.
4:00 Business Meeting, all are welcome.
8:30 - 9:00 Registration (Refreshments - Pastries, Coffee, Tea, Juice)
9:00 - 9:25 Genetics as a Tool for Determining the Relationship Between Ethanol Preference and Ethanol Self-Administration.
Mary C. Ritz, Frank R. George and Richard A. Meisch, University of Minnesota.
9:25 - 9:50 Oral Ethanol Self-Administration in Mice: Relationship to Ethanol Preference in Inbred Mice.
Gregory I. Elmer, Richard A. Meisch and Frank R. George, University of Minnesota.
9:50 - 10:15 Acute and Chronic Morphine Dependence in the Pigeon: Application of Three~Key Drug Discrimination Procedures.
Charles France, University of Michigan.
10:15 - 10:40 The Discriminative Stimulus Effects of d-Amphetamine In Humans.
Larry D. Chait, E.L. Uhlenhuth, and Chris-Ellyn Johanson, University of Chicago.
1O:40 - 10:45 Break
10:45 - 11:10 Phenylpropanolamine: Behavioral Effects, Neurochemistry and Interaction with d-amphetamine in rats.
Arthur P. Leccesse, Jordan H. Cohen and William H. Lyness, Texas Tech University.
11:10 - 11:35 Instructions Control the Ability of Nicotine to Serve as a Reinforcer.
John R. Hughes, Roy W. Pickens, William Spring and Robert M. Keenan, University of Minnesota.
11:35 - 12:00 A Randomized, Placebo-controlled Study of the Effects of Dose on Nicotine Gum Self-Administration.
Steven W. Gust and John R. Hughes, University of Minnesota.
12:00 - 1:15 Lunch
1:15 - 1:40 The Conditioned Place Preference Test as a Means of Investigating Drugs as Reinforcers.
L. D. Reid, C. L. Hubbell and S. A. Czirr, Rensselaer Polytechnic Institute.
1:40 - 2:05 Oral Self-Administration of Diazepam and Triazolam in the Baboon: Dissociation Between Drug Preference and Physiological Dependence.
Nancy A. Ator, Roland R. Griffiths and Bettye L. Campbell, Jonns Hopkins University.
2:05 - 2:30 Diazepam Self-Administration in Naive Rhesus Monkeys.
Kathleen A. Grant and Chris-Ellyn Johanson, University of Chicago.
2:30 - 2:55 Abuse Liability and Reinforcing Efficacy of Triazolam in Humans.
John D. Roache and Roland R. Griffiths, Johns Hopkins University.
2:55 - 3:00 Break
3:00 - 3:25 Self-Administration of Phencyclidine (PCP) and PCP Analogues by the Rat.
N. L. .Goodman and J. E. Moreton, University of Maryland.
3:25 - 3:50 The Progressive Ratio Method for Evaluating Strength of Reinforcement of IV Self-Administered Drugs Using Rats.
James R. Weeks and James R. Collins, Weeks Laboratory Specialties and The Upjohn Company.
3:50 - 4:15 Environmental Modification of Tolerance to Morphine's Discriminative 5timulus Properties in Rats.
Christine A. Sannerud and Alice M. Young, Wayne State University.
4:15 - 4:40 Discriminative Stimulus Properties of MK-212: Effects of Serotonin Agonists and Antagonists.
J.P. Appel, K.A. Cunningham and P.M. Callahan, University of South Carolina.
4:40 - 5:05 Antagonism by Indomethacin of Oral Ethanol Self-Administration.
Frank R. George, University of Minnesota.
5:05 ISGIDAR Business Meeting
Brain Sites Involved in the Mediation of the Behavioral Effects of Intraventricularly Administered (-)-Nicotine.
Victor J. DeNoble, Yvonne P. Dragan and Paul C. Mele, Phillip Morris Co.
Patterns of Ethanol Consumption as a Function of Ethanol Access Schedule and Level of Food Deprivation. Henry Marcucella, Boston University.
8:30 Registration
9:00 Intranasal Cocaine Self-Administration: Lack of Tolerance to Pressor Effects.
R.W. Foltin, M.W. Fischman and J. Pedrosa, The Johns Hopkins University School of Medicine, Baltimore, MD.
9:25 Reinforcing Properties of Amphetamine in At-Risk Populations.
H. deWit and C.E. Johanson, The University of Chicago, Chicago, IL.
9:50 Effect of Cigarette Rod Length on Smoking Topography.
P.P. Woodson and R.R. Griffiths, Francis Scott Key Medical Center, Baltimore, MD.
10:15 Coffee break
10:45 Euphoriant Response to Diazepam Predicts Response to Lorazepam and Halazepam but not to Alprazolam.
J.O. Cole, M. Bird, M.H. Orzack, E. Dessain and Loren Friedman, McLean Hospital, Boston, MA.
11:10 Historical and Contextual Determinants of the Effects of Neurotoxin Lesions on Morphine Self-Administration.
S.I. Dworkin and J.E. Smith, LSU School of Medicine, Shreveport, LA.
11:35 Behavioral Disruption Due to Termination of Intravenous Cocaine Self-Administration in Rats.
M.E. Carroll, S.T. Lac and S. Nygaard, University of Minnesota, Minneapolis, MN.
12:00 Lunch
1:00 The Mouse as a Tool in Behavioral Pharmacology: The Establishment and Maintenance of Oral Ethanol Self-Administration in Inbred Mice.
G.I. Elmer, R.A. Meisch and F.R. George, NIDA Addiction Research Center, Baltimore, MD.
1:25 Intracranial Self-Administration: The Current Status.
N.E. Goeders, LSU School of Medicine, Shreveport, LA.
1:50 Self-Administration of Methylenedioxymethamphetamine (MDMA) by Rhesus Monkeys.
P.M. Beardsley, R.L. Balster and L.S. Harris, Medical College of Virginia, Richmond, VA.
2:15 Pharmacological Modification of the Stimulus Properties of Psychomotor Stimulants.
W.L. Woolverton, R.M. Virus and J.B. Kamien, The University of Chicago, Chicago, IL.
2:40 Coffee break
3:15 The Discriminative Stimulus Properties of Pentobarbital Stereoisomers and Other Drugs in Pigeons Trained to Discriminate Pentobarbtial from Saline.
W.D. Wessinger and G.R. Wenger, University of Arkansas for Medical Sciences, Little Rock, AR.
3:40 Three-Choice Discrimination Between d-Amphetamine, Fenfluramine and Saline in Pigeons.
S.M. Evans and C.E. Johanson, The University of Chicago, Chicago, IL.
4:15 Opiate Receptor Modulation of the Pentylenetetrazol Stimulus.
M.W. Emmett-Oglesby and A. Herz, Max Planck Institute for Psychiatry, Munich, FRG.
4:40 Business Meeting
8:00 Registration
9:00 Intravenous Self-Administration of Antihistamines by Rhesus Monkeys.
P.M. Beardsley, R.L. Balster and L.S. Harris, Medical College of Virginia, Richmond, VA.
9:30 Second-Order Cocaine Self-Administration in the Rat: Comparison of Intravenous and Subcutaneous Routes of Administration.
W.A. Corrigall, S. Herling, K.M. Coen and G. Palmer, Addiction Research Foundation, Toronto, Canada
10:00 Evidence for D2-Receptor Involvement in Tolerance to the Discriminative Stimulus Properties of Cocaine.
M.W. Emmett-Oglesby and D.M. Wood, Texas College of Osteopathic Medicine, Ft. Worth, Texas.
10:30 The Discriminative Stimulus Properties of Antihistamines in Pigeons.
S.E. Evans, J.P. Zacny, C.E. Johanson and W.L. Woolverton, University of Chicago, Chicago, IL.
11:00 The Regularity of Marihuana Self-Administration in a Residential Environment.
R.W. Foltin, M.W. Fischman and J.V. Brady, Johns Hopkins Medical School, Baltimore, MD.
11:30 Oral Cocaine Self-Administration in C57BL/6J Mice.
F.R. George, G.I. Elmer and S.R. Goldberg, National Institute on Drug Abuse, Baltimore, MD.
12:00 Lunch
1:00 Anxiogenic Property of the Putative Ethanol Antagonist RO 15-4513 in a Pentylenetetrazol Discrimination.
C.M. Harris, D. Benjamin and H. Lai, Texas College of Osteopathic Medicine, Ft. Worth, TX.
1:30 Caffeine as a Reinforcer in Moderate Coffee Drinkers.
J.R. Hughes, S.T. Higgins, S. Gulliver and G. Mireault, University of Vermont, Burlington, VT.
2:00 Chronic Self-Administration of Nicotine and Placebo Gums by Abstinent Smokers.
J.R. Hughes, S.T. Higgins, S. Gust and R. Keenan, University of Vermont, Burlington, VT.
2:30 Self-Administration of Orally Delivered Ethanol by Rhesus Monkeys: Choice Between Different Amounts of Concurrently Available Ethanol.
R.A. Meisch and G.A. Lemaire, University of Minnesota, Minneapolis, MN.
3:00 Acquisition and Generalization Measures of Sensitivity to Drug Stimuli.
L. Peoples and A. Tomie, Rutgers University, New Brunswick, NJ.
3:30 Discriminative Stimulus Effects of Intravenously Administered 1-Nicotine, d-Nicotine, 1-Nornicotine and 1-Cotinine in Squirrel Monkeys.
M.D. Swedberg, K. Takada, J.L. Katz and S.R. Goldberg, National Institute on Drug Abuse, Baltimore, MD.
4:00 Discriminative Stimulus Properties of PCP and Related Compounds in Pigeons Trained to Discriminate 5.0 mg/kg Pentobarbital from Saline.
W.D. Wessinger, University of Arkansas for Medical Sciences, Little Rock, AK.
4:30 Effects of Bromocriptine and Desmethylimipramine on Cocaine Self-Administration in Rhesus Monkeys.
W.L. Woolverton and M.S. Kleven, University of Chicago, Chicago, IL.
5:00 Business Meeting
8:00 Registration for ISGIDAR and SSPD “Drugs of Abuse” Session
8:30 SSPD: “Drugs of Abuse”
11:45 Lunch
1:15 Registration for ISGIDAR
1:30 Opening remarks - N.A. Ator
1:35 Intravenous Self-Administration of MK-801 by Rhesus Monkeys with Cocaine and Phencyclidine Self-Administration Histories.
P.M. Beardsley, J.M. Salay and R.L. Balster, Medical College of Virginia.
1:55 Influence of Physical Dependence on the Reinforcing Effects of Drugs.
Y. Wakasa, K. Takada and T. Yanagita, Central Institute for Experimental Animals, Japan.
2:15 Oral Self-Administration of Pentobarbital by Rhesus Monkeys under Concurrent Fixed-Ratio Schedules: Relative Reinforcing Effects of Different Pentobarbital Concentrations and Volumes.
R.A. Meisch and G.A. Lemaire, University of Minnesota Medical School.
2:35 Alteration of I.V. Cocaine Self-Administration in Rats by a Concurrently Available Non-drug Reinforcer.
M.E. Carroll, S.T. Lac and S.L. Nygaard, University of Minnesota Medical School.
2:55 Limited Access to Nicotine Self-Administration in Rodents.
W.A. Corrigall and K.M. Coen, Addiction Research Foundation and University of Toronto, Canada.
3:15 Break
3:30 The Role of Smoke Satiation Versus Changes in Draw in Accounting for the Decreases in Puff Volume which Occur as a Cigarette is Smoked.
P.P. Woodson and R.R. Griffiths, The Johns Hopkins University School of Medicine.
3:50 Effects of Drug History and Response Cost on the Self-Administration of Nicotine in Humans.
J.R. Hughes, University of Vermont.
4:10 Evaluating the Reinforcing Properties of Methocarbamol in Volunteers.
R.W. Foltin and M.W. Fischman, The Johns Hopkins University School of Medicine.
4:30 Effects of Food Deprivation on Subjective Responses to d-Amphetamine in Humans.
J.P. Zacny and H. de Wit, University of Chicago.
4:50 Concluding Remarks
5:00 Business Meeting - ISGIDAR members
8:30 Registration
9:00 Opening Remarks
9:05 The Behavioral Economics of Human Cigarette and Coffee Self-Administration.
Warren K. Bickel, John R. Hughes, Pamela Rizzuto, Stephen T. Higgins, University of Vermont, College of Medicine, Burlington, Vermont.
9:25 Pharmacology of Nicotine Self-Administration.
William A. Corrigall, and Kathleen M. Coen, Addiction Research Foundation and Department of Physiology, University of Toronto, Toronto, Canada.
9:45 Triazolam Self-Administration and Yohimbine Pretreatment Effects in Humans.
J.D. Roache, R.A. Meisch*, J.E. Henningfield*, S.A. Klein* and J.H. Jaffe*, University of Texas Health Science Center at Houston, Houston, Texas and *Addiction Research Center, NIDA, Baltimore, Maryland.
10:05 Invited Speaker: Choice and Alcohol Abuse.
Rudy E. Vuchinich, Department of Psychology, Wayne State University, Detroit, Michigan.
10:30 Coffee Break
10:50 ISGIDAR Travel Award: A Temporal Analysis of Fixed-Ratio Cocaine Self-Administration in Rhesus Monkeys.
Robert S. Mansbach and Robert L. Balster, Commonwealth of Virginia Center for Drug Abuse Research, Medical College of Virginia, Richmond, Virginia.
11:10 Attenuation of the Self-Administration of Cocaine by D1 and D2 Dopamine Antagonists in Squirrel Monkeys.
Jonathan B. Kamien, Jack Bergman and Roger D. Spealman, Laboratory of Psychobiology, Harvard Medical School and the New England Regional Primate Research Center, Southborough, Massachusetts.
11:30 Invited Speaker: Studies of the Neurochemical Substrates of Cocaine Self-Administration using a Progressive Ratio Schedule of Reinforcement.
David C.S. Roberts, Department of Psychology, Carleton University, Ottawa, Canada.
12:00 Lunch
2:00 Amphetamine, but Not Morphine, Produces Conditioned Place Preference in Chicks.
Bow Tong Lett, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
2:20 Environmental Variables Influencing Drug-Induced Adjunctive Responding in Rhesus Monkeys.
Michael A. Nader and William L. Woolverton, Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois.
2:40 Invited Speaker: Physiological and Subjective Effects of Smoked Cocaine in Human.
Dorothy K. Hatsukami, Department of Psychiatry, Research Unit, University of Minnesota Medical School, Minneapolis, Minnesota.
3:25 Coffee Break
3:40 Cocaine Choice in Human: Effects of Response Cost and Monetary Gain.
Richard W. Foltin and Marian W. Fischman, Department of Psychiatry and Behavioral Sciences, John Hopkins University School of Medicine, Baltimore, Maryland.
4:00 The Reinforcing Effects of Smoked Marijuana in Humans.
James P. Zacny and Larry D. Chait, Department of Psychiatry, University of Chicago School of Medicine, Chicago, Illinois.
4:20 Behavioral Dependence on PCP in Rats Performing Under a Multiple Fixed-Ratio Fixed-Interval Schedule.
William D. Wessinger and B.W. Massey, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
4:40 Meta-Analysis as a Regulatory Decision-Making Tool: Evaluating the Behavioral Safety of Drugs.
F.R. Funderburk, Linda L. Weinhold and *Ann T. Summerfelt, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine and *Maryland Psychiatric Research Center, Baltimore, Maryland.
5:00 Business Meeting - ISGIDAR members
8:30 Registration
9:00 Invited Speaker: The Generality of Animal-Based Principals: Implications for Drug Self-Administration Research.
Mark Galizio, University of North Carolina, Wilmington NC.
9:30 Effects of Buprenorphine on Cocaine-Based Smoking in Monkeys and Self-Administration of Other Reinforcing Substances in Rats and Monkeys.
Marilyn Carroll and Sylvie T. Lac, University of Minnesota, Minneapolis.
10:00 Reinforcing Effectiveness of Opioids in Rhesus Monkeys.
Gail Winger and James H. Woods, Ann Arbor, MI.
10:30 A Molecular Analysis of Fixed-Ratio Behavior Maintained by Alfentanil, Cocaine and Ketamine.
Student Travel Awardee Paul Skjoldager, Ann Arbor, MI.
11:00 Invited Speaker: The role of the Nucleus Accumbens in the Reinforcing Action of Drugs.
George Koob, Scripps Clinic, LaJolla, CA.
11:30 A Study on the Reinforcing Efficacy and Infusion Speed of Nicotine in Rhesus Monkeys.
Yoshio Wakasa, Kawasaki, Japan.
12:00 Lunch
1:00 Choice Between Smoked and Intravenous Cocaine in Humans.
Richard Foltin and Marian Fischman, Johns Hopkins University, Baltimore.
1:30 Human Conditioned Flavor Preference Based on Pairing with Caffeine.
Thomas S. Critchfield, R.R. Griffiths and Kenneth Silverman, Johns Hopkins University, Baltimore.
2:00 Differential Subjective, Behavioral and Physiological Effects After Single Versus Divided Doses of Orally-Administered Pentobarbital.
Harriet deWit, Betsy Bodker and John Ambre, University of Chicago and Northwestern University.
2:30 Food-Drug Choice in an Open and Closed Economy.
Bill Woolverton and Mike Nader, University of Chicago.
3:00 Orally-Delivered Cocaine as a Reinforcer in Rhesus Monkeys.
Dick Meisch, Frank George and Greg Lemaire, University of Texas.
3:30 Opiate Self-Administration in BALB/CJ, C57BL/6J and the Mu-Deficient CXBK/By Mice.
G.I. Elmer, S.R. Goldberg and F.R. George, NIDA-ARC, Baltimore.
4:00 Business Meeting
8:30 Coffee and registration
9:00 Invited Speaker: Pavlovian Conditioning in Study of Drug Reward.
Chris Cunningham, Department of Medical Psychology, Oregon Health Sciences University, Portland, Oregon.
9:30 Tolerance to the Reinforcing Effects of Cocaine.
Michael Emmett-Oglesby, Clay Pickering and John Lane, Texas College of Osteopathic Medicine.
9:50 Invited Speaker: Serotonergic Involvement in Amphetamine Self-Administration in Rats. Michael Lyness, Texas Tech University Health Sciences Center.
10:20 Subjective and Reinforcing Effects of Subanesthetic Doses of Nitrous Oxide in Healthy Volunteers.
Student Travel Awardee Cathleen Dohrn, The University of Chicago.
11:00 Break
11:20 Methodological Issues in the Measurement of Drug Reinforcement in Humans: Some Examples from Caffeine Research.
John R. Hughes, Alison H. Oliveto, Warren K. Bickel, Stephen T. Higgins, Susan E. Terry, The University of Vermont.
11:40 Caffeine Self-Administration in Humans Using a Cumulative Dosing Procedure.
Suzette M. Evans, Thomas Critchfield and Roland R. Griffiths, The Johns Hopkins University.
12:00 Lunch
1:30 Invited Speaker: Microdialysis Studies of Psychomotor Stimulants and Opiate Dependence in the Nucleus Accumbens.
Bartley Hoebel, Princeton University.
2:00 MU1 Opioid Receptors Mediate the Reinforcing Effects of Heroin.
Steve Negus, Gavril Pasternak, Matthew Weinger, Sondra Mattox and George Koob, Research Institute at Scripps Clinic.
2:20 Genetic Variation in Opiate Receptor Populations Differentially Affects Numerous Opiate-Related Drug Effects Including Drug Reinforced Behavior.
Gregory I. Elmer, Jeanne O'D.Pieper, Steven R. Goldberg and Frank George, NIDA ARC, Baltimore.
2:40 The Effects of Chlorpromazine and Clozapine on the Reinforcing Effects and the Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys.
Kimberly Vanover and William Woolverton, The University of Chicago.
3:00 Break
3:30 Marijuana Self-Administration in a Residential Laboratory.
Thomas H. Kelly, Richard Foltin and Marian Fischman, The John Hopkins University School of Medicine.
3:50 Cocaine-Food Choice by Rhesus Monkeys: Open vs. Closed Economies.
Michael Nader and William Woolverton, The University of Chicago
4:10 Behavioral Economics of Drug Self-Administration: A Re-analysis of the Nicotine Regulation Hypothesis.
Richard J. DeGrandpre, University of Vermont.
4:30 Orally Delivered Midazolam as a Reinforcer for Rhesus Monkeys.
Richard A. Meisch, Gregory A. Lemaire and John D. Roache, University of Texas, Houston.
4:50 Stretch Break
5:00 Business meeting
8:30 Registration
9:00 Diazepam-Reinforced Self-Medication Behavior in Anxious Patients.
John D. Roache, Melinda A. Stanley and Daniel L. Creson, University of Texas Health Science Center at Houston.
9:20 Variability in Response to Cocaine's Reinforcing Effects: Results of Human and Animal Studies.
Susan Schenk and Emily S. Davidson, Texas A & M University.
9:40 Effects of Income on Drug Choice in Humans.
Student Travel Awardee Richard J. DeGrandpre, University of Vermont.
10:00 What is Reinforcement? A Genetic Approach to Questions in Behavioral Pharmacology.
Frank George, University of New Mexico.
10:20 Coffee Break
11:00 The High-Efficacy D1 Dopamine Receptor Agonist SKF 81297 as a Candidate Therapeutic for Cocaine Dependence.
Student Travel Award Finalist Sharon Rosenzweig-Lipson, Harvard University.
11:20 Oral Alprazolam Reinforcement in Baboons.
Nancy A. Ator and Roland R. Griffiths, Johns Hopkins University.
11:40 The Effects of Reinforcement Schedule History on Cocaine Self-Administration by Rhesus Monkeys.
Michael A. Nader, University of Chicago.
12:00 Lunch
1:30 Subjective Effects of Ethanol and Diazepam: Correlates of Drug Self-Administration.
Student Travel Award Finalist Mary Ann D. Chutuape, University of Chicago.
1:50 Caffeine as a Reinforcer in 10-15 Year Old Soda Drinkers: Preliminary Results.
John R. Hughes, Alison H. Oliveto, Stephen T. Higgins, Warren K. Bickel, William Valliere and Sue Terry, University of Vermont.
2:10 Invited Speaker: Genetic Differences in Appetitive Effect of Abused Drugs.
Tsutomu Suzuki, Hoshi University.
2:30 Vascular Access Ports for Intravenous Drug Delivery in Squirrel Monkeys.
Jack Kinsora and David A. Downs, Parke-Davis Pharmaceutical Research Division.
2:50 Break
3:30 The Subjective, Cognitive and Psychomotor Effects of Subanesthetic Doses of an Intravenous General Anesthetic Propofol, in Healthy Volunteers.
James P. Zacny, University of Chicago.
3:50 Orally Self-Administered Cocaine in Rhesus Monkeys: Transition from Negative or Neutral Behavioral Effects to Positive Reinforcing Effects.
Richard A. Meisch, University of Texas Health Science Center at Houston.
4:10 Effects of a Non-Drug Option on Intravenous Cocaine Choice by Humans.
Richard W. Foltin and Marian W. Fischman, John Hopkins University.
4:30 Break
4:40 Business meeting
8:30 Registration
9:00 Tolerance to the Reinforcing Effects of Cocaine in a Progressive Ratio Paradigm.
DH Li, RY Depoorlene and M.W. Emmett-Oglesby, Texas College of Osteopathic Medicine.
9:20 Alcohol Dose Choice by Humans: Effects of Social Context and Performance Impairment.
T.H. Kelly, R.W. Foltin and M.W. Fischman, University of Kentucky and Columbia University.
9:40 Effects of Buprenorphine and Naltrexone in a Model of Cocaine Relapse in Rats.
Student Travel Awardee S.D. Comer, University of Minnesota.
10:00 Self-Medication in Anxious Individuals: Effects of Ethanol and Diazepam.
M.A. Chutuape and H. de Wit, University of Chicago.
10:20 Coffee Break
11:00 Reinstatement of Extinguished Cocaine-Taking Behavior by Cocaine and Caffeine.
S. Schenk. Texas A & M University.
11:20 A Comparison of the Behavioral and Physiological Effect of Buprenorphine and Morphine in Healthy Volunteers.
L. Amass, W.K. Bickel and S.T. Higgins, University of Vermont.
11:40 Invited Speaker: Psychostimulant Influences on Conditioned Place Preference Behavior of Rhesus Monkeys.
S.M. Pomerantz, University of Pittsburgh.
12:00 Lunch
1:30 Nicotine Action in the Ventral Tegmental Region in Nicotine Self-Administration.
W.A. Corrigall and K.M. Coen, Addiction Research Foundation.
1:50 The Effect of Response-Dependency on Nucleus Accumbens Extracellular Dopamine Levels During Intravenous Cocaine Administration in Rats.
S.E. Hemby, J.E. Smith and S.I. Dworkin, Wake Forest University.
2:10 Invited Speaker: The Use of Choice Procedures for the Analysis of the Reinforcing Properties of Alcoholic Beverages in Rats.
G.M. Heyman, Harvard University.
2:30 Comparison of Oral Discrimination and Reinforcing Effects of Phencyclidine, Ketamine and Dizocilpine in Rhesus Monkeys.
E.D. Pakarinen, K. Schwarz-Stevens and J.H. Woods, University of Michigan.
2:50 Break
3:30 The Reinforcing Effects of Dopamine D1 Agonists in Rhesus Monkeys.
M.R. Weed and W.L. Woolverton, University of Chicago.
3:50 Orally Delivered Methadone as a Reinforcer for Rhesus Monkeys.
R.A. Meisch, J. Grabowski and R.B. Stewart, University of Texas Houston-Health Science Center.
4:10 Stimulus Effect of Ethyl-6-Carboline-3-Carboxylate in Rhesus Monkeys.
K. Takada and T. Yanagita, Cental Institute for Experimental Animals, Japan.
4:30 Break
4:40 Business meeting
8:00 Registration, continental breakfast
9:00 Invited Speaker: Effects of Stressors and Gender on Opioid Self-Administration in Rats*.
Neal Grunberg.
9:45 The Dopamine Agonist 7-Oh-DPAT Shifts the Cocaine Self-Administration Dose-Effect Function to the Left Under Different Schedules in the Rat.
Student Travel Award Winner S. Barak Caine and George Koob.
10:15 Dose Pain Increase the Reinforcing Effects of Nitrous Oxide?
Vesna Pirec and James Zacny.
10:45 Break
11:00 Role of A1 and A2 Adenosine and D1 Dopamine Receptors in the Ability for Caffeine to Reinstate Extinguished Cocaine-Taking Behavior.
Susan Schenk and Carol McNamara.
11:30 Effects of Two Dopamine Antagonists on Responses to d-Amphetamine in Healthy Volunteers.
Lisa Brauer.
12:00 Lunch (optional - $12 charge)
1:30 Self-Injection of Midazolam in Baboons: Drug Reinforcement and Physical Dependence.
Elise Weerts, Barbara Kaminski and Roland Griffiths.
2:00 Effects of 2B-Propanoyl-3B-(4-Toluyl)-Tropane (PPT) on Responding Maintained by Intravenous Cocaine Infusions in Rats.
S.E. Hemby, D. Meloni, H.M. Davies, J.E. Smith and S.I. Dworkin.
2:30 The Interaction of Buprenorphine with Cocaine-Morphine Combinations.
Richard Foltin and Marian Fischman.
3:00 Sedative Maintained Behavior in Baboons: Roles of Anxiety and Drug Withdrawal.
Richard Lamb and Roland Griffiths.
3:30 Break
3:45 Oral Cocaine Reinforcement: Similarities and Differences with Oral Phenobarbital Reinforcement.
Richard Meisch, Robert Stewart and Mitchell Macenski.
4:15 Business meeting
*Dedicated to Sandi Jochum
8:00 Registration ($25)
9:00 An Animal Model of Cocaine Craving.
S.M. Evans and R.W. Foltin.
9:20 Naltrexone Antagonism of Operant Ethanol Self-Administration.
M. Kelley-Poole and F.R. George.
9:40 Opioid Self-Administration in Humans: Effects of Dose and Alternative Reinforcer.
S.J. Heishman, J.E. Henningfield, C.R. Schuster and S.R. Goldberg.
10:00 Coffee Break
10:20 Conditions Sufficient for the Production of Oral Self-Administration of Cocaine or Lidocaine Solutions in Preference to Water.
J.L. Falk, A. Siris and C.E. Lau.
10:40 A Comparison of Cocaine, Nicotine and Pseudoephedrine Facilitation of Brain Stimulation Reward.
M.A. Bozarth, C.M. Pudiak and R. KuoLee.
11:00 Invited Speaker: Reexamining Reinforcer Efficacy: Methods, Measures and Metrics.
W.K. Bickel.
11:45 Lunch
1:00 Morphine Self-Administration Behavior in Transgenic Super-Oxide Dismutase Mice.
G.I. Elmer, J.L. Evans, S.R. Goldberg, C.J. Epstein and J.L. Cadet.
1:20 Caffeine Self-Administration and Withdrawal Among Cola and Coffee Drinkers.
A. Liguori and J.R. Hughes.
1:40 Relative Reinforcing Effects of Different Doses of Methadone.
R.A. Meisch, N.S. Want and R.B. Stewart.
2:00 Nicotine Self-Administration in Humans.
K.A. Perkins, J.E. Grobe, D.Weiss and A. Caggiula.
2:20 Coffee Break
2:40 Examination of the Rewarding Properties of Nicotine in Rats: Effects of Nicotine Pre-Exposure.
M. Shoaib, C.W. Schindler, I.P. Stolerman and S.T. Goldberg.
3:00 Are Self-Administered Drug and Food Economic Substitutes?
R.W. Foltin.
3:20 Influence of Physostigmine on the Reinforcing Effects of Cocaine and Methamphetamine in Rats.
K. Takada and T. Yanagita.
3:40 Drug Choice in Monkeys: Concurrent VI Schedules of Reinforcement.
W.L. Woolverton.
4:00 Business meeting
9:00 Behavioral Technology and the Study of Drug Abuse Disorders.
Leshner.
9:30 Experimental Analysis of Benzodiazepine Reinforcement in Patient Populations: Attempts to Distinguish Between Positive and Negative Reinforcement.
Roache and Meisch.
9:50 Alcohol History Modulates the Reinforcing and Subjective Effects of Nitrous Oxide in Volunteers.
Zacny, Cho, Marks, Klafta, Young, Coalson and Toledano.
10:10 Effects of Benzodiazepine on Human Methadone Self-Administration and Naltrexone on Human Ethanol Self-Administration.
Spiga, Meisch, Grabowski, Roach and Johnson.
10:30 Break
10:50 Genetic and Environmental Factors in Nicotine Self-Administration.
Shoaib, Schindler and Goldberg.
11:10 Effects of Continuous Cocaine Infusions on Food- and Cocaine-Maintained Responding in Rhesus Monkeys.
Glowa and Fantegrossi.
11:30 Matching of Drug-Reinforced Responding of Rhesus Monkeys under Concurrent Non-Independent VR VR Schedules.
Meisch and Spiga.
11:50 Lunch
1:30 Schedule Induction Conditions Not Only Exaggerate Intake But Also Enhance Drug Solution Choice.
Falk, Lau and Neal.
1:50 Evaluating the Reinforcing Efficacy of Orally-Delivered Drugs and a Non-Drug Reinforcer Using Progressive Ratio Schedules.
Rodefer and Carroll.
2:10 Break
2:30 Self-Administered Cocaine Serves as an Economic Substitute for Food in Baboons.
Comer and Foltin.
3:50 Assessing Relative Reinforcer Efficacy: Within Subject Comparison of Procedures.
Bickel, DeGrandpre and Madden.
4:10 Effects of Antagonist Drugs: A Behavioral Economic Re-analysis.
Madden, Bickel and DeGrandpre.
4:30 Business meeting
9:00 Does information modulate reinforcing or other effects of nitrous oxide in healthy vounteers?
Zacny.
9:30 Difficulties in establishing oral amphetamine as a reinforcer.
Meisch and Macenski.
10:00 Oral cocaine as a reinforcer for rhesus monkeys: The role of conditioned flavor preferences.
Meisch.
10:30 Non-contingent reinforcer delivery: effect of alternatives and reinforcer magnitude.
Foltin and Evans.
11:00 Cocaine and procaine self-administration under progressive ratio schedules in monkeys.
Sonntag, Rowlett and Woolverton.
11:30 Effects of corticosterone on cocaine self-administration in rats: Role of type I and type II corticosteroid receptors.Mantsch and Goeders.
12:00 Lunch
1:30 Psychostimulant-induced increases in responding for electrical brain stimulation in female vs. male rats.
Statman, Milholland and Craft.
2:00 Is caffeine reinforcing in rodents?
Dworkin and Gatto.
2:30 Delay discounting in opioid-dependent patients and non-drugf-control participants: Drug and monetary rewards.
Madden, Petry and Bickel.
3:00 Oral triazolam self-administration in baboons revisited.
Ator.
3:30 Business meeting
9:05-9:30
EFFECT OF ABT-431, A SELECTIVE D1 AGONIST, ON SMOKED COCAINE SELF-ADMINISTRATION IN HUMANS
Haney, M., Collins, E.D., Foltin, R.W., Fischman, M.W. New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York, NY, U.S.A.
9:30-9:55
A CHOICE PROCEDURE FOR STUDYING ORAL AMPHETAMINE SELF-ADMINISTRATION BY BABOONS.
Foltin, R. W. New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York, NY, U.S.A.
9:55-10:20
EFFECTS OF REPRODUCTIVE CYCLE ON OPERANT RESPONDING FOR COCAINE AND SUCROSE.
G.S. Hecht, N.E. Spear & L.P. Spear, Dept. of Psychology and The Center for Developmental Psychobiology, Binghamton University, Binghamton, NY, 13902, U.S.
10:20-10:45
REINFORCEMENT FREQUENCY AS A DETERMINANT OF DRUG CHOICE: DOES DRUG CLASS MATTER?
Karen G. Anderson and William L. Woolverton, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS
10:45-11:10
FIRING PATTERNS OF SINGLE NUCLEUS ACCUMBENS NEURONS IN RATS INTRAVENOUSLY SELF-ADMINISTERING COCAINE
Laura L. Peoples, Anthony J. Uzwiak, Fred Gee, and Mark O. West. Department of Psychology, Rutgers, The State University of New Jersey, New Brunwick NJ 08903
11:10-11:35
EFFECTS OF SOCIAL STRESS AND THE AVAILABILITY OF AN ALTERNATIVE, NONDRUG REINFORCER ON ACQUISITION OF COCAINE SELF-ADMINISTRATION IN GROUP HOUSED CYNOMOLGUS MONKEYS.
D. Morgan, K. Grant, J. Kaplan, R. Mach, and M. Nader. Wake Forrest University School of Medicine, Dept. of Physiology and Pharmacology, Winston Salem, NC 27101
11:35-12:00
NALTREXONE PRETREATMENT DECREASES THE REINFORCING EFFICACY OF ETHANOL AND SACCHARIN BUT NOT PCP OR FOOD UNDER CONCURRENT PROGRESSIVE-RATIO SCHEDULE IN RHESUS MONKEYS.
Joshua Rodefer. Department of Psychology, University of North Caroline at Chapel Hill, Chapel Hill, NC 27599-3270
12:00-1:00
LUNCH
1:00-1:15
IS FOOD-MAINTAINED BEHAVIOR THE APPROPRIATE CONTROL FOR DETERMINING SELECTIVITY OF PHARMACOTHERAPY?
Marilyn E. Carroll, Ph.D. and Una C. Campbell, Ph.D. University of Minnesota, Department of Psychiatry, Minneapolis, MN 55455
1:15-1:40
REINFORCING EFFECTS OF CAFFEINE, EPHEDRINE AND THEIR BINARY COMBINATION IN RATS.
Richard J. Briscoe. University of Michigan Medical School, Dept. of Pharmacology, Ann Arbor, MI 48109-0632
1:40-2:05
INDIVIDUAL DIFFERENCES IN BIPHASIC EFFECTS OF ETHANOL.
Louis Holdstock and Harriet de Wit. The University of Chicago, Dept. of Psychiatry, Chicago, IL 60637.
2:05-2:30
MEASURES OF THE ORAL REINFORCING EFFECTS OF DRUGS IN RHESUS MONKEYS.
James H. Woods and Jeffrey Vivian. University of Michigan Medical School, Dept. of Pharmacology, Ann Arbor, MI 48109-0632
2:30-2:55
E PLURIBUS UNUM OR E UNUM PLURIBUS? REINFORCEMENT AND ITS MEASUREMENT. Warren K. Bickel, Gregory J. Madden, and Eric Jacobs. University of Vermont, Burlington, VT 054001
3:00-3:15
COFFEE BREAK
3:15-3:30
RELATIVE REINFORCING EFFECTS OF DRUGS ASSESSED BY PERSISTENCE AND PREFERENCE.
Richard A. Meisch, M.D., Ph.D. Dept. of Psychiatry & Behav. Science, University of Texas, Houston, TX 77030
3:30-3:55
MEASUREMENT OF RELATIVE REINFORCING EFFICACY OF DRUGS OF ABUSE USING THE METRIC OF RESPONSE OUTPUT.
William L. Woolverton, Ph.D., Department of Psychiatry and Human Behavior University of Mississippi Medical Center, Jackson, MS; James K. Rowlett, Ph.D. Harvard Medical School, New England Regional Primate Research Center, Southborough, MA
3:55-4:20
Invited Commentary: MEASURING THE REINFORCING EFFICACY OF DRUGS". Peter R. Killeen, Ph.D. Arizona State University, Tempe, AZ 85287
4:30
BUSINESS MEETING
8:45-9:00 COFFEE & ROLLS
9:05-9:30
Invited Speaker : PERSPECTIVES ON THE REINFORCING FUNCTIONS OF DRUGS Brady, J. V. Department of Neuroscience, Johns Hopkins School of Medicine, Bayview, MD, U.S.A.
9:30-9:55
METHODOLOGICAL EXAMINATION OF ALPRAZOLAM REINFORCEMENT IN ANXIOUS PATIENTS Roache, J. D.. University of Texas Health Science Center at San Antonio, Department of Psychiatry, San Antonio, TX, U.S.A.
9:55-10:20
CONDITIONED EFFECTS OF ENVIRONMENTAL STIMULI PAIRED WITH SMOKED COCAINE IN HUMANS Foltin, R. W. New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York, NY, U.S.A.
10:20-10:45
INTRAVENOUS DRUG SELF-ADMINISTRATION IN DRUG- AND EXPERIMENTALLY-NAIVE MICE Bespalov, A. Y., Kuzmin, A.V., Semenova, S. G., Patkina, N. A., and Zvartau, E.E. Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia.
10:45-11:10
INDIVIDUAL DIFFERENCES IN THE ACQUISITION OF IV COCAINE SELF-ADMINISTRATION UNDER EXTENDED ACCESS CONDITIONS IN RATS: EFFECTS OF DOSE AND RELATIONSHIP TO FEEDING, DRINKING AND HOME-CAGE LOCOMOTOR BEHAVIORS Mantsch, J. R., Ho, A., Schlussman, S.D., and Kreek, M.J. The Laboratory of the Biology of Addictive Diseases, The Rockefeller University. New York, NY 10021, U.S.A.
11:10-11:35
THE EFFECTS OF THE NITRIC OXIDE SYNTHASE INHIBITOR 7-NITROINDAZOLE ON BEHAVIORS RELATED TO COCAINE ABUSE Collins, S.. Department of Psychology, Boston University, Boston, MA 02215, U.S.A.
11:35-12:00
3,4-METHYLENEDIOXYMETAMPHETAMINE (MDMA, "ECSTASY") IS A ROBUST REINFORCER in rats Gerald Zernig, Elisabeth Ratzenboeck, and Alois Saria Division of Neurochemistry, Department of Psychiatry, Univ. Innsbruck, A-6020 Innsbruck, Austria.
12:00-1:00 LUNCH
1:00-1:25
THE REINFORCING EFFECTS OF ETHANOL ACROSS THE MENTRUAL CYCLE IN WOMEN. Louis Holdstock. Department of Psychology, The University of Chicago, Chicago, IL 60637, U.S.A.
1:25-1:50
NONINDEPENDENT CONCURRENT RATIO SCHEDULES: NUMBER OF RESPONSES PER DRUG DELIVERY AS A DEPENDENT VARIABLE Meisch, R. A. and Spiga, R. UT Psychiatry-Houston, Department of Psychiatry & Behavioral Science, 1300 Moursund, Houston, TX 77030-3497, U.S.A.
1:50-2:15
PREFERENCE PROCEDURES IN HUMAN DRUG SELF-ADMINISTRATION RESEARCH: PROBLEMS AND POTENTIAL SOLUTIONS Diana J. Walker and James P. Zacny. The University of Chicago, Department of Anesthesia & Critical Care, 5841 S. Maryland Ave., MC4028, Chicago, IL 60637 U.S.A.
2:15-2:40
PROPENSITY TO SELF-ADMINISTER COCAINE IN MICE EXPRESSING REDUCED LEVELS OF DOPAMINE TRANSPORTER. Rocha, B., Zhuang, X., and Hen, R.. Behavioral Neuroscience, N.I.D.A./ Intramural Research Program, Baltimore, MD, U.S.A.
2:40-3:05
EFFECTS OF DOPAMINE D1-LIKE AND D2-LIKE AGONISTS ON COCAINE SELF-ADMINISTRATION IN RHESUS MONKEYS: RAPID ASSESSMENT OF COCAINE DOSE-EFFECT FUNCTIONS S. Barak Caine, S. Steven Negus, and Nancy K. Mello. McLean Hospital-Harvard Medical School, Belmont, MA, U.S.A.
3:05-3:20 COFFEE BREAK
3:20-5:30
SYMPOSIUM: "BEHAVIORAL SELECTIVITY IN THE EVALUATION OF CANDIDATE DRUG ABUSE MEDICATIONS" J. Bergman & P. Beardsley chair
(please hold questions to presenters until the end of the last presentation)
3:25-3:40
A PRACTICAL PERSPECTIVE ON THE NEED FOR SPECIFICITY MEASURES: THE NIDA MDD EXPERIENCE D. J. McCann, National Institutes On Health, National Institute On Drug Abuse, Medications Development Division, Rockville, Md 20892-9551
3:40-4:00
PRECLINICAL ASSESSMENT OF THE EFFICACY AND SAFETY OF DRUG ABUSE TREATMENTS S. Negus McLean Hospital-Harvard Medical School, Belmont, MA, U.S.A.
4:00-4:20
SACCHARIN SELF-ADMINISTRATION AS A CONTROL FOR SPECIFICITY OF TREATMENT EFFECTS ON COCAINE SELF-ADMINISTRATION IN RATS S. Shenk, Texas A&M University, Department of Psychology, College Station, TX 77843, U.S.A.
4:20-4:40
WHAT'S SO BAD ABOUT SOME BEHAVIORAL DISRUPTION AND MODEST ABUSE LIABILITY IN A PHARMACOTHERAPY? M. A. Nader, Depts. of Physiology & Pharmacology and Radiology, The Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, U.S.A.
4:40-5:00
COMPARISONS OF THE EFFECTS OF GBR 12909 AND PHENTERMINE ON RESPONDING MAINTAINED BY FOOD AND COCAINE. J. R. Glowa, M. LeSage and D. Stafford, LSUMC-S, Shreveport, LA 71130, U.S.A.
5:00-5:30
COMMENT: J. Katz, National Institute on Drug Abuse/ Intramural Research Program, Baltimore, MD, U.S.A. & Audience Discussion
5:30 (estimated) Business Meeting
8:00 Registration
8:30 Opening Remarks - Richard W. Foltin, President
8:40 William E. Fantegrossi & James E. Goeders (Emory University): What's drug got to do with it? Is "escalation" of drug self-administration a specific model for addiction?"
9:00 Gerald Zernig, Jose A. Crespo, Petra Stöckl & Alois Saria (Medical University Innsbruck): Why we see sensitization only to psychostimulants but not opioids.
9:20 Collins & Woods (University of Michigan): Reinforcing effects of quinpirole in rats. (Student award applicant)
9:40 S. Barak Caine (Harvard University): Self-administration of the D2/D3 agonist 7-OHDPAT in rats: influence of history, schedule of reinforcement and comparison with a D3 selective agonist.
10:00 Coffee Break
10:20 Dick Meisch & Ralph Spiga (University of Texas HSC-H): Convergence of measures of relative reinforcing effects: The relation between the relative persistence of responding and normalized demand curves.
10:40 Richard De La Garza (UCLA): A preliminary analysis of the impact of GVG treatment on methamphetamine self-administration and subjective effects in methamphetamine-dependent participants.
11:00 Morgane Thomsen, Howard H. Gu, & S. Barak Caine (Harvard University): Mice carrying a mutant cocaine-insensitive dopamine transporter do not self-administer cocaine. (Student award applicant)
11:20 Richard Yi, Delia West, & Warren K. Bickel (University of Arkansas for Medical Sciences): Binge eating symptoms, Obesity and temporal discounting.
11:40 James MacKillop, Sean O'Hagen, James Murphy, John McGeary, & Stephen Lisman (Brown University): Subjective craving for alcohol reflects a state-dependent increase in the relative reinforcing efficacy of alcohol.
12:00 Lunch (90 min) For those who paid of course!
1:30 Chesley J. Christensen, Alan Silberberg, Steven R. Hursh, Mary E. Huntsberry, Peter G. Roma & Anthony L. Riley (American University): The Reinforcing Strength of Cocaine is less than Food but Increases with Increased Cocaine Self-Administration History as Measured Using a Recently Developed Exponential Model of Demand. (Student award applicant)1:50 Ian Stolerman (King’s College, London): Update on Databases.
2:10 Ziva Cooper (Columbia University): (Student award applicant)
2:30 Meg Haney (Columbia University): Aripiprazole & cocaine self-administration.
2:50 Coffee Break
3:10 Elise Weerts (Johns Hopkins): TBA
3:30 Thomas Newton (UCLA): The effects disulfiram treatment on cocaine self-administration in cocaine-dependent participants: Preliminary findings.
3:50 Kirshenbaum, A.P., Hughes, D.M., & Brown, S.J (Saint Michael’s College): DRL performance and nicotine administration: A systematic investigation of dose and schedule requirement.
4:10 Best for last (brief talks of great interest)
4:30 Business Meeting -- Election of new Secretary