The ISGIDAR NEWSLETTER

VOL. 22, NO. 2
November, 1996

INTERNATIONAL STUDY GROUP INVESTIGATING DRUGS AS REINFORCERS

CORRESPONDENCE
ABOUT ISGIDAR:
(President of ISGIDAR)		ABOUT ISGIDAR NEWSLETTER:
(Secretary of ISGIDAR)
R. J. Lamb
DART (MS 984)
Medical College of Pennsylvania and
Hahnemann University
Department of Psychiatry
Broad & Vine Streets
Philadelphia, PA 19102-1192
tel: (215) 762-8387
email: LAMBR@HAL.HAHNEMANN.EDU
 Patrick M. Beardsley, Ph.D.
Medical College of Virginia
Department of Pharmacology & Toxicology
P. O. Box 980613
410 N. 12th St., Smith Bld. #756A
Richmond, VA 23298-0613
tel: (804) 828-5185
email: PBEARDSLEY@GEMS.VCU.EDU

1996 ISGIDAR SCIENTIFIC MEETING -- SAN JUAN, PUERTO RICO

The program from the June, 1996 ISGIDAR meeting held in San Juan, Puerto Rico is available here. The meeting commenced with a provocative presentation by Dr. Alan Leshner, Director of NIDA, in which he identified his priority interest as "drug craving" and the development of technology to measure and modify it. Presentations by the membership of results from recent self-administration research followed involving both laboratory animal and human studies utilizing the oral, intravenous, and inhalation routes of administration. Issues emerged during and after the meeting regarding how the meeting and its luncheon should be held and regarding which I (the Secretary) am now strongly soliciting opinions from ISGIDAR members. Some of these issues involved the luncheon. While many members thought the luncheon was a nice setting to informally meet and talk shop others complained about the costs and the quality and variety of food offered. Some suggested having the luncheon somewhere less expensive than the CPDD Meeting's home hotel. Other issues included whether there should be discounts for those pre-registering for the meeting as opposed to registering on site and whether abstracts should be published in a scientific journal or not. I would like to hear from members regarding these issues (preferably by email to my address above). If I am able to accumulate sufficient comment from members I will be in a better position to include ballots in the next newsletter (and before the next ISGIDAR Meeting) with which the membership could vote on specific alternatives. Your comment and vote could shape how we conduct our next meeting. Specifically, consider and comment upon the following issues:
  1. Should the costs for the luncheon be contained within a specific range and if so what range (e.g., $10-$15, $15-$20, or whatever)?
  2. What is your preferred format for lunch (e.g., buffet, box lunch, lunch off-site)?
  3. Should there be a luncheon? What about an alternative such as having the meeting at night with a snack/pay bar (a nightly meeting may permit the more senior members who are typically at board meetings to attend)?
  4. Should the abstracts be published?
  5. Should there be reductions in registration costs for those who pre-register?
  6. Please comment upon any other issues you think may be worth discussion or membership vote in this regard.
I also encourage submission of any notice or news story which would be of interest to the membership and which could be included in a subsequent newsletter.

MEMBERSHIP

New members

Lisa Brauer

Nominations for membership

CandidateInstitutionSponsor
Mohammed ShoaibNIDA-ARCSteve Goldberg
Joshua RodeferUniversity of MinnesotaMarilyn Carroll
Mitch MacenskiUniversity of TexasDick Meisch
John GlowaLouisiana State University Medical SchoolRick Lamb

ISGIDAR WEB SITE

The CPDD Electronics Communication Subcommittee has mounted an ISGIDAR Web Site as a satellite of CPDD's Web Site. Currently the site holds some contact information for ISGIDAR, lists the programs from about the last decade (1984-1996; 1985 is missing) and this newsletter. If you have the program from 1985 or years previous to 1984, please contact Jonathan Kamien at 303 316-7171 or email them to Jonathan Kamien or Ron Wood. Also, we are still looking for contributions of ISGIDAR-related content*, so please contribute these materials. Thanks.

*ISGIDAR-related content might include:

POST-DOCTORAL POSITIONS AND FELLOWSHIPS

POSTDOCTORAL POSITION

A postdoctoral position is available in the Psychobiology Section of the Intramural Research Program at the National Institute on Drug Abuse, ADDICTION RESEARCH CENTER. Research focuses on the behavioral and neurochemical effects of drugs of abuse and particularly, the pharmacological mechanisms that underlie the behavioral effects of abused drugs. Current emphasis is on the behavioral effects of cocaine and related stimulants. Behavioral studies examine psychomotor stimulant actions, discriminative stimulus effects, and reinforcing effects. Neurochemical studies include receptor binding, functional assays of neurotransmitter uptake, and regulation of second messenger function. Applicants should have a strong interest in pharmacology and behavioral science and received a Ph.D. degree within the last five years. Interested individuals should send curriculum vitae to: Jonathan L. Katz, Psychobiology Section, NIDA Addiction Research Center, P.O. Box 5180, Baltimore, MD 21224, USA. Telephone: 410/550-1533. E-Mail: jkatz@irp.nida.nih.gov

POSTDOCTORAL RESEARCH FELLOWSHIPS

JOHNS HOPKINS SUBSTANCE ABUSE RESEARCH. Postdoctoral human research positions available in a stimulating and productive environment with excellent clinical and research resources. Human Laboratory Behavioral Pharmacology. Design and implement controlled laboratory research on the behavioral, subjective, and physiological effects of psychoactive drugs for abuse liability testing and medications development. Drug classes under study include: opioids, cocaine, anxiolytics, caffeine, nicotine. Research background and experience required. Applied Research in Behavioral Treatment of Substance Abuse. Develop and evaluate treatment interventions for opioid and cocaine abusers and cigarette smokers. Sites include methadone, outpatient and smoking cessation clinics. Minorities encouraged. USPHS stipend levels based on experience. Send vita, letter of interest, and names/phones of 3 references to George E. Bigelow, Ph.D., Roland Griffiths, Ph.D. or Maxine L. Stitzer, Ph.D., BPRU, Behavioral Biology Research Center,. 5510 Nathan Shock Drive, Johns Hopkins Bayview Campus, Baltimore, Maryland 21224-6823. (410) 550-0035.

POSTDOCTORAL POSITIONS

MEDICAL COLLEGE OF VIRGINIA, DEPARTMENT OF PHARMACOLOGY. Postdoctoral research positions are available in laboratory animal behavioral pharmacology. Positions are possible utilizing almost any behavioral pharmacological approach to the study of the behavioral and/or neurochemical mechanisms mediating the activity of the drugs of abuse. Ongoing studies utilize mice, rats, squirrel monkeys, and rhesus monkeys in discrimination, self-administration, and other operant and respondent procedures involving several routes of drug administration including the intravenous, oral, and inhalation routes. Of particular current emphasis are studies involving the pharmacology of excitatory amino acid agents, the development of medications for the treatment of drug-dependency disorders, the pharmacology of behaviorally-active inhalation agents, and the development of drug relapse procedures synthesizing operant and respondent methodologies. Many opportunities exist for collaborating with other researchers in the department who have major research foci upon the cannabinoids, nicotine, and the opiates. Send vita, letter of interest, and names and telephone numbers of 2 references to: Patrick M. Beardsley, Ph.D. or Robert L. Balster, Ph.D.; Medical College of Virginia, Department of Pharmacology, P.O. Box 980613, Richmond, VA 23298-0613. (804) 828-5185.

BIBLIOGRAPHY

This is a listing of recent (1995-1996) publications on drug reinforcement or on the behavioral pharmacology of drugs of abuse submitted by ISGIDAR members: RA=reprint available; IP=in press; NA=reprint not available.

William L. Woolverton, Ph.D., Professor and Director
Division of Neurobiology and Behavior Research
Department of Psychiatry and Human Behavior
University of Mississippi Medical Center
2500 N. State Street Jackson, MS 39216
phone: 601-984-58984 FAX: 601-984-5899
  1. RA Rowlett, J.K., Massey, B.W., Kleven, M.S. and Woolverton, W.L.: Parametric analysis of cocaine self-administration under a progressive-ratio schedule inrhesus monkeys. Psychopharmacology 125: 361-370, 1996.

  3. IP Woolverton, W.L.: Intravenous self-administration of cocaine under concurrent VI schedules of reinforcement. Psychopharmacology, in press.

  5. IP Rowlett, J.K. and Woolverton, W.L.: Assessment of benzodiazepine receptor heterogeneity in vivo: Apparent pA2 and pKb analyses from behavioral studies. Psychopharmacology, in press.

  7. IP Rowlett, J.K. and Woolverton, W.L.: Discriminative-stimulus effects of zolpidem in pentobarbital-trained subjects: I. Comparison with triazolam in rhesus monkeys and rats. J. Pharmacol. Exp. Ther., in press.

  9. IP Rush, C.R., Madakasira, S., Goldman, N.H., Woolverton, W.L. and Rowlett, J.K.: Discriminative-stimulus effects of zolpidem in pentobarbital-trained subjects: II. Comparison with triazolam and caffeine in humans. J. Pharmacol. Exp. Ther., in press.

Marilyn E. Carroll, Ph.D.
Department of Psychiatry
The University of Minnesota
Box 392 UMHC
Minneapolis, MN 55455
  1. Comer SD, Turner DM and Carroll ME: Effects of food deprivation on cocaine-base smoking in rhesus monkeys. Psychopharmacology, 119:127-132, 1995.

  3. Comer SD, Lac ST, Curtis LK and Carroll ME: Food deprivation affects extinction and reinstatement of responding in rats. Psychopharmacology, 121:150-157, 1995.

  5. Carroll ME and Comer SD: Animal models of relapse. Experimental and Clinical Psychopharmacology. 4:11-18, 1996.

  7. Rodefer JS, DeRoche, KK, Lynch WA and Carroll ME (1995) Feeding conditions alter the demand for phencyclidine and ethanol: A behavioral economic analysis. Experimental and Clinical Psychopharmacology, 4:61-67, 1996.

  9. Mattox A. and Carroll ME (1995) Smoked heroin self-administration in rhesus monkeys. in preparation. Psychopharmacology, 125:195-201.

  11. Comer SD, Lac ST, Wyvell CL and Carroll ME (1996) Combined effects of buprenorphine and a nondrug alternative reinforcer on i.v. cocaine self-administration in rats maintained under FR schedules, Psychopharmacology, 125:355-360.

  13. Gahtan E, LaBounty LP, Wyvell C, and Carroll ME (1995) The relationship between saccharin consumption, oral ethanol and IV cocaine self-administration. Pharmacology Biochemistry and Behavior, 53:919-925.

  15. Rawleigh JM, Rodefer JS, Hansen JJ and Carroll ME (1996) Combined effects of buprenorphine and an alternative nondrug reinforcer on phencyclidine self-administration in rhesus monkeys. Experimental and Clinical Psychopharmacology, 4:68-76.

  17. Comer SD and Carroll ME (1996) Oral caffeine pretreatment produced modest increases in cocaine self-administration in rhesus monkeys. Psychopharmacology, in press.

  19. Carroll ME and Lac ST (1996) Acquisition of i.v. amphetamine and cocaine self-administration in rats as a function of dose. Psychopharmacology, in press.

  21. Rodefer JS and Carroll ME (1996) Progressive ratio and behavioral economic evaluation of the reinforcing efficacy of orally-delivered phencyclidine and ethanol in monkeys: Effects of feeding conditions. Psychopharmacology, in press.

  23. Carroll ME: Interactions of food and addiction. In: Niesink R.J.M. and Kornet M.L.M.W. (Eds.) Behavioral Toxicology and Addiction: Food, Drugs and Environment, The Netherlands: Open University Press, 1996.

  25. Carroll ME, Mattox AJ: Drug reinforcement in animals. In: Johnson BA and Roache JD (Eds.) Drug Addiction and its Treatment: Nexus of Neuroscience and Behavior. Raven Press: New York, in press, 1996.

  27. Carroll ME: Acquisition and reacquisition (relapse) of drug abuse: Modulation by alternative reinforcers. In Wetherington CL and Falk J (Eds.) Laboratory Behavioral Studies of Vulnerability to Drug Abuse. NIDA Research Monograph , 1995.

B.G. Hoebel
Department of Psychology
Princeton University
Princeton, NJ 08544-1010
  1. Hernandez, L. & Hoebel, B. G. Chronic clozapine selectively decreases prefrontal cortex dopamine as shown by simultaneous cortical, accumbens and striatal microdialysis in freely moving rats. Pharmacology Biochemistry & Behavior, 1995, 52, 581-589.

  3. Hoebel, B. G., Rada, P., Mark, G. P. & Hernandez, L. The power of integrative peptides to reinforce behavior by releasing dopamine. In F. L. Strand, B. E. Beckwith, B. Chronwall & C. A. Sandman (Eds.) Models of Neuropeptide Action, Annals of the New York Academy of Sciences, New York, 1995, 739, 36-41.

  5. Mark, G. P., Weinberg, J. B., Rada, P. V. & Hoebel, B. G. Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus. Brain Research, 1995, 688, 184-188.

  7. Parada, M. A., Puig de Parada, M. & Hoebel, B. G. Rats self-inject a dopamine antagonist in the lateral hypothalamus where it acts to increase extracellular dopamine in the nucleus accumbens. Pharmacology Biochemistry & Behavior, 1995, 52, 179-187.

  9. Parada, M. A., Puig de Parada, M., Hernandez, L. & Hoebel, B. G. Triple electrical channels on a triple fluid swivel and its use to monitor intracranial temperature with a thermocouple. Journal of Neuroscience Methods, 1995, 60, 133-139.

  11. Pothos, E. N., Hernandez, L. & Hoebel, B. G. Chronic food deprivation decreases extracellular dopamine in the nucleus accumbens: Implications for a possible neurochemical link between weight loss and drug abuse. Obesity Research, 1995, 3, 525S-529S.

  13. Puig de Parada, M., Parada, M. A., Pothos, E. & Hoebel, B. G. d-Fenfluramine, but not d-norfenfluramine, uses calcium to increase extracellular serotonin. Pharmacology Letters, 1995, 56, PL415-420.

  15. Pothos, E. N., Creese, I. & Hoebel, B. G. Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine and food intake. Journal of Neuroscience, 1995, 15, 6640-6650.

  17. Hoebel, B. G., Rada, P. V., Mark, G. P., Parada, M., Puig de Parada, M., Pothos, E. & Hernandez, L. Hypothalamic control of accumbens dopamine: A system for feeding reinforcement. In G. A. Bray & D. H. Ryan (Eds.) Molecular and Genetic Aspects of Obesity, LSU Press, Baton Rouge, 1996, Pennington Center Nutrition Series, Vol. 5, 263-280.

  19. Rada, P. V., Mark, G. P., Taylor, K. M. & Hoebel, B. G. Morphine and naloxone, ip or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex. Pharmacology Biochemistry & Behavior, 1996, 53, 809-816.

William D. Wessinger, Ph.D.
Department of Pharmacology and Toxicology, Slot 611
University of Arkansas for Medical Sciences
4301 W. Markham Street
Little Rock, AR 72205
  1. Wessinger, W. D.: Sexual dimorphic effects of chronic phencyclidine in rats. Eur. J. Pharmacol. 277:107-112, 1995. (RA)

  3. Burke, T. F., S. Buzzard and W. D. Wessinger: [3H]MK-801 binding to well-washed rat brain membranes following cessation of chronic phencyclidine treatment. Pharmacol. Biochem. Behav. 51:435-438, 1995. (RA)

  5. Li, M., H. R. Garner, W. D. Wessinger and D. E. McMillan: Effects of food deprivation and satiation on sensitivity to the discriminative-stimulus effects of pentobarbital in pigeons and morphine in rats. Beh. Pharmacol. 6:724-731, 1995. (RA)

  7. Garner, H. R., W. D. Wessinger and D. E. McMillan: Effects of multiple discrimination reversals on acquisition of a drug discrimination task in rats. Beh. Pharmacol. 7:200-204, 1996. (RA)

  9. Valentine, J. L., M. Mayersohn, W. D. Wessinger, L. W. Arnold and S. M. Owens: Antiphencyclidine monoclonal Fab fragments reverse phencyclidine-induced behavioral effects and ataxia in rats. J. Pharmacol. Exp. Ther. 278:709-716, 1996. (RA)

ISGIDAR BIBLIOGRAPHY SUBMISSIONS

The pressroom of the ISGIDAR Newsletter encourages submission of recent references from its membership. References should be submitted only electronically either by diskette mailed to the address below or via email (a bin hex attachment works fine) to PBEARDSLEY@GEMS.VCU.EDU. Please send references in a format akin to JPET format. Almost any word processing file format (PC or Mac) is digestible.

Thanks,

The Management

For ISGIDAR BIBLIOGRAPHY SUBMISSIONS, please transmit references to:
Patrick M. Beardsley, Ph.D.
Medical College of Virginia
Department of Pharmacology & Toxicology
P. O. Box 980613
410 N. 12th St., Smith Bld. #756A
Richmond, VA 23298-0613
tel: (804) 828-5185
email: PBEARDSLEY@GEMS.VCU.EDU

NOMINATIONS FOR ISGIDAR

Everyone is encouraged to submit nominations for ISGIDAR membership to the president at the address at the top of this page. New members are essential to maintaining ISGIDAR as a vigorous organization. A letter of recommendation and vita are needed to be considered.